Vibrational spectroscopy in cell therapy

Cell therapy is transforming the way we treat cancer and immune disorders. It offers living, personalized treatments like CAR T that can adapt to each patient. However, making these therapies reliable, scalable, and safe remains a major challenge. At nanoGUNE, we are developing vibrational spectroscopy tools to provide real-time molecular insights into both the manufacturing process and patient response. Our goal is to unlock the full potential of cell-based therapies by improving their monitoring—from bioreactor to bedside.

We design SERS sensors and micro-reactor platforms compatible with in situ Raman measurements, which allows us to track cell state, metabolism and quality during production, without interrupting the process. The same technology is used to analyze patient samples—small drops of plasma or serum—to predict how well a treatment works or whether adverse effects may appear. By combining these measurements with AI, we turn spectral fingerprints into actionable insights. Our work is at the interface of nanotechnology, spectroscopy, and immunotherapy, and we actively collaborate with other research groups as well as clinical and industrial institutions to put these frontiers forward