DIPC Community Seminar: Flavin photocatalysis for the activation and delivery of metallodrugs

DIPC Community Seminar

In recent years, our research has demonstrated the efficacy of flavins and flavoproteins as selective and efficient photocatalysts in activating metal-based anticancer drugs [1-3]. Specifically, we have illustrated that flavin catalysts can photoconvert Pt(IV) precursors into clinically approved Pt(II) agents in the presence of bioreductants, thereby inducing antiproliferative effects in cancer cells with minimal light exposure [1]. Unconventionally, metal complexes act as substrates in these reactions, rather than catalysts as commonly observed in catalysis. In this contribution, I will emphasize how we have leveraged this chemistry to develop novel strategies for activating and
delivering anticancer metallodrugs [4,5].

[1] S. Alonso-de Castro, E. Ruggiero, A. Ruiz-de-Angulo, E. Rezabal, J. C. Mareque-Rivas, X. Lopez, F. López-Gallego, L. Salassa, Chem. Sci., 8, 4619 (2017).[2] S. Alonso-de Castro, A. L. Cortajarena, F. López- Gallego, L. Salassa, Angew. Chem. Int. Ed., 57, 3143 (2018).
[3] J. Gurruchaga-Pereda, V. Martínez-Martínez, E. Rezabal, X. Lopez, C. Garino, F. Mancin, A. L. Cortajarena, L. Salassa, ACS Catal., 10, 187 (2020).[4] S. Velasco-Lozano, S. Alonso-de Castro, C. Sanchez-Cano, A. I. Benítez-Mateos, F. López-Gallego, L. Salassa, Chem Sci, 13, 59 (2022).
[5] L. F. Mazzei, J. Gurruchaga-Pereda, Á. Martínez, J.Calvo Martínez, L. Salassa, A. L. Cortajarena, Chem. Commun., 59, 4754 (2023).

Zoom: https://dipc-org.zoom.us/j/97048979421

Youtube: https://youtube.com/live/hRjr8mhhpH8